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WebHere we show that mice lacking talin-1 in intestinal epithelial cells (Tln1 Δepi) have heightened susceptibility to colonic disease caused by the A/E murine pathogen Citrobacter rodentium. Tln1 Δepi mice exhibit decreased survival, and increased colonization, colon weight, and histologic colitis compared to littermate Tln1 fl/fl controls. best free family movies on xfinity WebJun 11, 2024 · Furthermore, there was no difference in myeloid immune cell recruitment in Ifnlr1 − / − compared to WT mice (fig. S6, A to D), and depletion of neutrophils did not affect bacterial burden (fig. S6E). Thus, IFN-λ signaling in epithelial cells is necessary and sufficient to induce susceptibility to a secondary infection. 401 derby down way wilmington nc