Reactome_signaling_by_erbb4

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August undefined, 2024

WebCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 297 genes : Gene families ?: Categorize these 297 genes by gene family : Show members (show 321 source identifiers mapped to 297 genes)

Nuclear signaling by ERBB4 Pathway - PubChem

WebMar 19, 2024 · ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. The ErbB4 signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of alpha-dystrobrevin1. WebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. … small red dots on legs and feet swollen

ERBB4 Signaling Pathway (Concept Id: C2984396)

Webreactome_nuclear_signaling_by_erbb4 reactome_nucleotide_binding_domain_ leucine_rich_repeat_containing_rece ptor_nlr_signaling_pathways … WebThe ErbB receptors signal through Akt, MAPK, and many other pathways to regulate cell proliferation, migration, differentiation, apoptosis, and cell motility. ErbB family members and some of their ligands are often over-expressed, amplified, or mutated in many forms of cancer, making them important therapeutic targets. WebJul 1, 2024 · The network was also significantly enriched for Reactome signaling pathways relevant for erythropoiesis, ... ErbB4 signaling has not previously been implicated in blood development or homeostasis ... highline united methodist church burien

Applied Sciences Free Full-Text ErbB4 Is a Potential Key …

[PDF] Signaling by ERBB4 Semantic Scholar

WebFeb 28, 2024 · We found that genes regulating the expression of the upregulated genes (i.e., upstream regulators) were enriched in the “signaling by ERBB4” pathway. ERBB4 was also one of three genes... WebLog-likelihood per target Total log-likelihood Term Description; 0.3: 3.3: REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE: Genes involved in Translocation of ZAP-70 to highline united methodist churchWebFeb 28, 2024 · We found that genes regulating the expression of the upregulated genes (i.e., upstream regulators) were enriched in the “signaling by ERBB4 ” pathway. ERBB4 was also one of three genes encoding master regulators whose expression was increased only in samples with an NTRK fusion. Moreover, the algorithm searching for positive feedback … small red dots on legs itchy

"http://www.reactome.org/content/detail/1227986 " - Reactome_signaling_by_erbb4

Reactome_signaling_by_erbb4

Erbb4 erb-b2 receptor tyrosine kinase 4 [ (house mouse)]

WebMar 21, 2024 · ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with ERBB4 include Amyotrophic Lateral Sclerosis 19 and … WebERBB4 is a single-pass type I transmembrane protein with multiple furin -like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins -2, -3 and -4, heparin-binding EGF-like growth factor and betacellulin.

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WebThe ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. 22 publications Caution WebREACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2: Systematic name: M29814: Brief description: Constitutive Signaling by Overexpressed ERBB2: Full description or abstract : Collection: C2: Curated CP: Canonical Pathways CP:REACTOME: Reactome Pathways: Source publication : Exact source: R-HSA-9634285: Related gene sets

WebERBB4 Signaling Pathway (Concept Id: C2984396) The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:jc, PMID:16460914, Reactome:R-HSA-1236394] ERBB4 Signaling Pathway MedGen UID: WebErbB4 signaling is growth inhibitory and may be coupled to tumor suppression in prostate cells Results report the 2.4 A crystal structure of the extracellular region of human ErbB4 …

WebNov 3, 2015 · The epidermal growth factor receptor (EGFR) family member ERBB4, which forms signaling complexes with other EGFR family members, can undergo ligand-induced proteolytic cleavage to release a soluble intracellular domain (ICD) that enters the nucleus to modify transcription. Web48 rows · Erbb4 is expressed in the GABAergic neurons of the bed nucleus stria terminalis, a part of the extended amygdala. Inhibition of NRG1-triggered ERBB4 signaling induces …

WebNuclear signaling by ERBB4. Besides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A …

WebREACTOME_SIGNALING_BY_ERBB4: Systematic name: M544: Brief description: Signaling by ERBB4: Full description or abstract : Collection: C2: Curated CP: Canonical Pathways … small red dots on lower legs not itchyWebReactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and ... isoforms, PI3K-induced AKT signaling (Hazan et al. … highline university mentor programWebJun 12, 2024 · The results indicate that ERBB4 is a unique coregulator of ER, directly coupling extranuclear and nuclear estrogen actions in breast cancer and proposes that the contribution of an autocrine ER BB4/ER signaling pathway to tumor growth and therapeutic response should be considered when managing patients with ER-positive breast cancer. … small red dots on my stomachWebJun 7, 2024 · Proinflammatory macrophages are essential drivers of colitis and express the growth factor receptor ErbB4. This study tested the role of ErbB4 and its specific ligand, NRG4, in regulating macrophage function. We show that endogenous NRG4-ErbB4 signaling limits macrophage production of proinflammatory cytokines in vitro and limits colitis … highline united llcWebERBB4 Signaling Pathway (Concept Id: C2984396) The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and … highline urologyWebApr 14, 2024 · Impaired ErbB4 signaling in the hypothalamus of HFD-fed mice. A,B) Metabolic tissue-specific expression levels of Nrg4 and ErbB4 were measured in lean … highline us connectWebAt least three and possibly four splicing isoforms of ERBB4 exist that differ in their C-tail and/or the extracellular juxtamembrane regions: ERBB4 JM-A CYT1, ERBB4 JM-A CYT2 and ERBB4 JM-B CYT1 (the existence of ERBB4 JM-B CYT2 has not been confirmed). The longest variant of each gene is displayed. highline upland ca