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Interplay between bacterial deubiquitinase and ubiquitin E3 ligase ...?

Interplay between bacterial deubiquitinase and ubiquitin E3 ligase ...?

WebJul 30, 2024 · E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin … WebMar 22, 2024 · INTRODUCTION. NEDD8 is a small protein that possesses high sequential and structural similarity to ubiquitin (Ub). As with protein ubiquitination, the conjugation of NEDD8 to substrates, referred to as neddylation, requires an enzyme cascade comprising NEDD8 E1 activating enzyme (NAE), NEDD8 E2 conjugating enzyme, and E3 NEDD8 … boulder tcu tickets WebSep 22, 2014 · Because other Shigella IpaH E3 ligase effectors, e.g., IpaH9.8 and IpaH4.5, had no appreciable ability to induce rapid macrophage cell killing (Fig. S1B), and because the observed IpaH7.8 activity was dependent on its E3 ligase activity (Fig. 2A and Fig. S1B), we concluded that IpaH7.8 is a key player in eliciting macrophage cell death during ... WebFeb 1, 2024 · Bacterial pathogens exploit host ubiquitin systems for their own benefit during infection. •. Bacterial pathogens have evolved specific T3SS or T4SS effectors that mimic … boulder tcx WebJun 7, 2024 · We apply this approach to identification of novel ubiquitin E3 ligases in pathogenic bacteria. Ubiquitination is an abundant protein post-translation modification … WebMar 1, 2024 · TRAF6, as an E3 ubiquitin ligase, is widely involved in autophagy induction due to its autoubiquitination and heteroubiquitination activities (25). ... The three bacteria were inoculated in liquid 2216E, LB, and nutrient broth media at 28, 37, and 35 °C, respectively, and shaken at 220 rpm overnight. ... 234 phone number country WebNEMO, Akt1. TRAF6 is an E3 ubiquitin ligase that functions as an adaptor protein in IL-1R, CD40, and TLR signaling. TRAF6 promotes NF-κB signaling through K63 polyubiquitination of IKK, resulting in IKK activation. TRAF6 has also been shown to ubiquitinate Akt1, causing its translocation to the cell membrane.

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