WebOct 17, 2014 · Finally, p53 regulates the transcription of genes that encode secreted proteins, such as interleukin 6, TNF-α, and S100B, which can modulate synaptic plasticity [12, 13]. Thus, which functional consequences might the brief activation of p53 have? WebApr 15, 2000 · Abstract Oligonucleotide microarrays were employed to quantitate mRNA levels from a large number of genes regulated by the p53 transcription factor. … do it yourself scrapbook album WebSep 15, 2024 · Homozygous deletion of Ets2 in p53 mutant mice resulted in strong down-regulation of snoRNAs and reversed the prometastatic phenotype of mutant p53 but had no effect on osteosarcoma development, which remained 100% penetrant. In summary, our studies identify Ets2 inhibition as a potential therapeutic vulnerability in p53 mutant … WebDec 6, 2006 · The p53-dependent gene expression signatures of four cell lines (MCF-7, ZR-75-1, and two immortalized human mammary epithelial cell lines) were identified by comparing p53-RNAi transduced cell lines to their parent cell lines. Cell lines were treated with vehicle only or doxorubicin to identify p53 responses in both non-induced and … contact kia motors finance WebAug 31, 2009 · Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 14 : 981–993. Article CAS PubMed PubMed Central Google Scholar WebQuality and integrity of mRNA was checked on the Agilent 2100 Bioanalyzer, and only samples with RIN values >9 were included for microarray analysis. Whole genome oligonucleotide-based gene expression microarray analysis was performed using the 4 × 44 K microarray format as described previously . Dual-color experiments were … do it yourself screened in porch ideas WebTranscriptomics analysis with microarray revealed 1317 differentially expressed genes. By integrated analysis of both omics data, we found nucleotides metabolism and sulfur-related metabolism are of great importance. Our study provided a pilot comprehensive view of the metabolism regulated by p53 and suggests several potential p53 targets in ...

WebMar 1, 2003 · Consistent with these findings, TKO mice lacking Arf, p53, and Mdm2 develop multiple and more aggressive tumors per animal than mice lacking either gene alone (7). We have now used oligonucleotide and cDNA … http://genesdev.cshlp.org/content/14/8/981.long do it yourself scratch repair on car WebThe molecular mechanism responsible for Ewing’s Sarcoma (ES) remains largely unknown. MicroRNAs (miRNAs), a class of small non-coding RNAs able to regulate gene … WebInformation on gene expression in colon tumors versus normal human colon was recently generated by an oligonucleotide microarray study [1]. We used the associated database to search for genes that display age-dependent variations in expression. Statistically significant evidence was obtained that such genes are present in both the tumor and … contact kia motors Web36 rows · Apr 1, 2000 · We report an investigation of p53-regulated gene expression using oligonucleotide ... WebAnalysis of p53-regulated gene expression patterns using oligonucleotide arrays . × ... Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. 2000. Maureen Murphy. Download Download PDF. Full PDF Package Download Full PDF Package. This Paper. contact kfc near me WebApr 1, 2000 · Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. ...

WebAug 25, 2009 · A study using overexpression of p53 in human ovarian cancer cells reported that ≈80% of 1,501 responsive genes were repressed by p53 ( 16 ). However, such … do it yourself screened in porch kits WebWe report an investigation of p53-regulated gene expression using oligonucleotide microarrays. EB-1 is a human colon carcinoma cell line containing a stably tranfected … contact kindle unlimited