Cyclothialidine
WebAug 26, 2024 · Cyclothialidine inhibits the ATPase activity of gyrase by competing for the ATP binding site . The precise mode of action of these agents with gyrase is incompletely understood, although ... WebAbstract. A total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was tested by preparing …
Cyclothialidine
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WebNov 11, 2003 · Concise Synthesis of Cyclothialidine Analogues (VI) with Ring Sizes from 12 to 15: Novel Macrocyclization Protocol Involving Reductive Thiolation. J. Geiwiz, J. Geiwiz. Pharma Div., Chem. Technol., F. Hoffmann-La Roche AG, CH-4070 Basel, Switz. Search for more papers by this author. WebTheir structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The …
WebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological ... WebCyclothialidine: ChEBI ID CHEBI:29566: Stars This entity has been manually annotated by a third party. Supplier Information Download Molfile XML SDF: Find compounds which contain this structure; Find compounds which resemble this structure; Take structure to the Advanced Search ...
WebCombining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives. Liane Saíz-Urra, Miguel Ángel Cabrera Pérez, Aliuska Morales Helguera, Matheus Froeyen. Pages 2736-2747 Download PDF. Article preview. WebCyclothialidine (Ro 09-1437) has been considered as a promising inhibitor whose modifications might lead to more potent compounds against the enzyme. We …
WebA total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was tested by preparing the lactone 13(Scheme 2) which contains the characteristic bicyclic core entity of 1.
WebCyclothialidine is an inhibitor of DNA gyrase. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use. Cyclothialidine, CAS 147214-63-9 Please contact us for prices and availability for the specification of product you are interested at. Product consultation Purity : 98% inbound mails in sapWebJan 1, 1993 · Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity … in and out mustard styleWebApr 14, 2011 · Abstract. The DNA gyrase inhibitor cyclothialidine had been shown to be a valuable lead structure for the discovery of new antibacterial classes able to overcome … inbound mapping exceptionWebJun 16, 1995 · Cyclothialidine contains a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain(21). Cyclothialidine exhibited the highest … inbound malicious ip address feedinbound mail via office 365WebCyclothiazide ( Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran ), sometimes abbreviated CTZ, is a benzothiadiazide ( thiazide) diuretic and … inbound mappingWebApr 1, 1996 · We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the... inbound marketing 2021